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Microbial acetyl-CoA metabolism and metabolic engineering

Anastasia Krivoruchko (Institutionen för biologi och bioteknik, Systembiologi) ; Yiming Zhang (Institutionen för biologi och bioteknik, Systembiologi) ; Verena Siewers (Institutionen för biologi och bioteknik, Systembiologi) ; Yun Chen (Institutionen för biologi och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för biologi och bioteknik, Systembiologi)
Metabolic Engineering (1096-7176). Vol. 28 (2015), p. 28-42.
[Artikel, refereegranskad vetenskaplig]

Recent concerns over the sustainability of petrochemical-based processes for production of desired chemicals have fueled research into alternative modes of production. Metabolic engineering of microbial cell factories such as Saccharomyces cerevisiae and Escherichia coli offers a sustainable and flexible alternative for the production of various molecules. Acetyl-CoA is a key molecule in microbial central carbon metabolism and is involved in a variety of cellular processes. In addition, it functions as a precursor for many molecules of biotechnological relevance. Therefore, much interest exists in engineering the metabolism around the acetyl-CoA pools in cells in order to increase product titers. Here we provide an overview of the acetyl-CoA metabolism in eukaryotic and prokaryotic microbes (with a focus on S. cerevisiae and E. coli), with an emphasis on reactions involved in the production and consumption of acetyl-CoA. In addition, we review various strategies that have been used to increase acetyl-CoA production in these microbes.

Nyckelord: Yeast, Bacteria, Acetyl-CoA, Central carbon metabolism, Industrial biotechnology

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Denna post skapades 2015-05-29. Senast ändrad 2017-01-17.
CPL Pubid: 217744


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Institutionen för biologi och bioteknik, Systembiologi



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Denna publikation är ett resultat av följande projekt:

Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO) (EC/FP7/247013)