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Kinetics of virus entry by endocytosis

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Biologisk fysik)
Physical Review E (1539-3755). Vol. 91 (2015), 4, p. Art. no. 042715.
[Artikel, refereegranskad vetenskaplig]

Entry of virions into the host cells is either endocytotic or fusogenic. In both cases, it occurs via reversible formation of numerous relatively weak bonds resulting in wrapping of a virion by the host membrane with subsequent membrane rupture or scission. The corresponding kinetic models are customarily focused on the formation of bonds and do not pay attention to the energetics of the whole process, which is crucially dependent, especially in the case of endocytosis, on deformation of actin filaments forming the cytoskeleton of the host cell. The kinetic model of endocytosis, proposed by the author, takes this factor into account and shows that the whole process can be divided into a rapid initial transient stage and a long steady-state stage. The entry occurs during the latter stage and can be described as a first-order reaction. Depending on the details of the dependence of the grand canonical potential on the number of bonds, the entry can be limited either by the interplay of bond formation and membrane rupture (or scission) or by reaching a maximum of this potential.



Denna post skapades 2015-05-21. Senast ändrad 2015-06-24.
CPL Pubid: 217374

 

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Institutioner (Chalmers)

Institutionen för teknisk fysik, Biologisk fysik (2007-2015)

Ämnesområden

Biologisk fysik
Cellbiologi

Chalmers infrastruktur