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The effect of ciprofloxacin injection on genetically absence prone (Wag/Rij) Rat's electroencephalogram characteristics

A. Moghimi ; S. Mollazadeh ; F. B. Rassouli ; Reza Shiee (Institutionen för signaler och system, Biomedicinsk elektromagnetik) ; M. A. Khalilzade
Basic and Clinical Neuroscience (2008-126X). Vol. 4 (2013), 1, p. 31-35.
[Artikel, refereegranskad vetenskaplig]

Introduction: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. Methods: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. Results: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. Discussion: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy.

Nyckelord: Absence epilepsy, Ciprofloxacin, EEG, Wag/rij, magnesium, 4 aminobutyric acid metabolism, absence, animal experiment, animal model, animal tissue, article, brain cortex, causal attribution, controlled study, ECG abnormality, electrode implant, electroencephalography, experimental rat, GABAergic system, male, neuropathology, neurotoxicity, nonhuman, pathophysiology, rat, risk assessment, seizure susceptibility, spike wave



Denna post skapades 2015-05-05. Senast ändrad 2016-04-29.
CPL Pubid: 216499

 

Institutioner (Chalmers)

Institutionen för signaler och system, Biomedicinsk elektromagnetik

Ämnesområden

Klinisk medicin

Chalmers infrastruktur