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Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

Harald Wutzel (Institutionen för kemi- och bioteknik, Polymerteknologi) ; F.H. Richter ; Y. Li ; S.S. Sheiko ; H.A. Klok
Polymer Chemistry (1759-9954). Vol. 5 (2014), 5, p. 1711-1719.
[Artikel, refereegranskad vetenskaplig]

Inverse emulsion reversible addition - fragmentation chain transfer (RAFT) polymerization has been used to generate N-(2-hydroxypropyl)methacrylamide (HPMA) based nanoparticles and reduction-sensitive nanogels with diameters of 100-200 nm. Inverse emulsion RAFT homopolymerization of HPMA afforded nanoparticles composed of linear PHPMA macromolecules with relatively narrow molecular weight distributions (Mw/Mn = 1.35-1.55). Copolymerization of HPMA with N,N′-bis(acryloyl)cystamine (BAC) at BAC to chain transfer agent ratios >1.5 resulted in crosslinked nanoparticles that could be isolated and redispersed in water. At smaller BAC to chain transfer agent ratios, non-crosslinked nanoparticles composed of (hyper)branched poly(N-(2-hydroxypropyl)methacrylamide-co-N,N′-bis(acryloyl)cystamine) copolymers were obtained. Addition of protein to the aqueous phase during the inverse emulsion copolymerization of HPMA and BAC allowed preparation of stimuli-responsive, protein-loaded nanogels, which were shown to release their payload under reductive conditions, e.g. upon exposure to tris(2-carboxyethyl) phosphine hydrochloride. These reduction-sensitive nanogels are of interest, e.g. as carriers for the delivery of proteins. © 2014 The Royal Society of Chemistry.



Denna post skapades 2015-05-05.
CPL Pubid: 216445

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Polymerteknologi (2005-2014)

Ämnesområden

Nanoteknik

Chalmers infrastruktur