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Influenza differentiation and evolution

Krzysztof Bartoszek (Institutionen för matematiska vetenskaper, matematisk statistik) ; P. Liò ; A. Sorathiya
Acta Physica Polonica B, Proceedings Supplement. Summer Solstice 2009 International Conference on Discrete Models of Complex Systems, Gdansk, Poland, 22-24 June 2009 (1899-2358). Vol. 3 (2010), 2, p. 417-452.
[Konferensbidrag, refereegranskat]

The aim of the study is to do a very wide analysis of HA, NA and M influenza gene segments to find short nucleotide regions, which differentiate between strains (i.e. H1, H2, ⋯ etc.), hosts, geographic regions, time when sequence was found and combination of time and region using a simple methodology. Finding regions differentiating between strains has as its goal the construction of a Luminex microarray which will allow quick and efficient strain recognition. Discovery for the other splitting factors could shed light on structures significant for host specificity and on the history of influenza evolution. A large number of places in the HA, NA and M gene segments were found that can differentiate between hosts, regions, time and combination of time and region. Also very good differentiation between different Hx strains can be seen. We link one of our findings to a proposed stochastic model of creation of viral phylogenetic trees.

Denna post skapades 2015-05-05. Senast ändrad 2017-07-03.
CPL Pubid: 216409


Institutioner (Chalmers)

Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)


Matematisk statistik

Chalmers infrastruktur