CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers

S.C. Coelho ; Sandra Rocha (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; P. Sampaio ; M.C. Pereira ; M.A.N. Coelho
Journal of Nanoparticle Research (1388-0764). Vol. 16 (2014), 4,
[Artikel, refereegranskad vetenskaplig]

Organic-inorganic hybrid nanoparticles are potential effective systems for drug delivery in cancer therapy and diagnosis. Chitosan-gum arabic with entrapped gold nanoparticles were developed as a carrier for an anticancer drug bortezomib. The nanosystem was designed to enhance the proteasome inhibitor activity in pancreatic cell lines, S2-013 and hTERT-HPNE. The hydrodynamic diameter of chitosan-gum arabic-gold nanoparticles loaded with bortezomib is around 330 nm. Laser scanning confocal microscopy images show the uptake of the gold nanoparticle/bortezomib encapsulated in chitosan-gum arabic matrix and the fast internalization of these nano combinations into pancreatic cells. Cytotoxic assays assessed that positively charged nanosystems reduce the cell growth and cell proliferation of S2-013s, but the same effect was not observed in cytotoxic response in hTERT-HPNE cells. The outcomes of this study demonstrate the capacity of chitosan-gum arabic nanocarriers to deliver gold nanoparticles/anticancer drug and to increase the permeation and retention effect in S2-013 cells and minimize drug side effects in HPNE cells. © 2014 Springer Science+Business Media.

Nyckelord: Cancer cells , Cellular uptake , Gold nanoparticles , Healthy effects , Polysaccharides

Denna post skapades 2015-05-05.
CPL Pubid: 216402


Läs direkt!

Länk till annan sajt (kan kräva inloggning)

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)



Chalmers infrastruktur