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N-[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, a molecule for radiohalogenation of proteins and peptides

Emma Aneheim ; Mark Foreman (Institutionen för kemi och kemiteknik, Kärnkemi) ; H. Jensen ; Sture Lindegren
Applied Radiation and Isotopes (0969-8043). Vol. 96 (2015), p. 1-5.
[Artikel, refereegranskad vetenskaplig]

In this work a new coupling reagent, N[2-(maleimido)ethyl]-3-(trimethylstannyl)benzamide, for radiohalogenation has been synthesized and characterized. The reagent is intended to either be attached to reduced disulfide bridges of proteins (making the halogenation site-specific) or to free terminal cysteine groups on peptides. The new reagent was also shown to be easily halogenated with inactive bromine and iodine as well as I-125 and At-211, indicating potential use within targeted radiotherapy.

Nyckelord: Halogenation, Astatine-211, Site specific antibody labelling, Peptide labelling, Targeted radiotherapy, Electrophilic aromatic substitution



Denna post skapades 2015-03-02. Senast ändrad 2015-10-27.
CPL Pubid: 213269

 

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Institutioner (Chalmers)

Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik (GU)
Institutionen för kemi och kemiteknik, Kärnkemi

Ämnesområden

Kemi

Chalmers infrastruktur