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Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

M.L. Martins ; A. Orecchini ; Luis Antonio Aguilera Medina (Institutionen för teknisk fysik, Kondenserade materiens fysik) ; J. Eckert ; J.P. Embs ; Aleksandar Matic (Institutionen för teknisk fysik, Kondenserade materiens fysik) ; M.J. Saeki ; H.N. Bordallo
EPJ Web of Conferences: 11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014; Autrans; France; 11 May 2014 through 16 May 2014 (2101-6275). Vol. 83 (2014), p. Art. no. 02011.
[Konferensbidrag, refereegranskat]

The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.

Denna post skapades 2015-02-11. Senast ändrad 2015-12-17.
CPL Pubid: 212414


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