CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

COX-2 regulation and TUNEL-positive cell death differ between genders in the secondary inflammatory response following experimental penetrating focal brain injury in rats.

Mattias Günther ; Stefan Plantman ; Johan Davidsson (Institutionen för tillämpad mekanik, Fordonssäkerhet) ; Maria Angéria ; Tiit Mathiesen ; Mårten Risling
Acta neurochirurgica (0942-0940). Vol. 157 (2015), 4, p. 649-659.
[Artikel, refereegranskad vetenskaplig]

Traumatic brain injury is followed by secondary neuronal degeneration, largely dependent on an inflammatory response. This response is probably gender specific, since females are better protected than males in experimental models. The reasons are not fully known. We examined aspects of the inflammatory response following experimental TBI in male and female rats to explore possible gender differences at 24 h and 72 h after trauma, times of peak histological inflammation and neuronal degeneration.

Nyckelord: TBI, COX-2, iNOS, Sex, Gender, Secondary inflammation



Denna post skapades 2015-01-22. Senast ändrad 2015-04-20.
CPL Pubid: 211370

 

Läs direkt!


Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för tillämpad mekanik, Fordonssäkerhet

Ämnesområden

Hållbar utveckling
Neurovetenskap

Chalmers infrastruktur