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Gold and silver nanoparticle-assisted laser desorption ionization mass spectrometry compatible with secondary ion mass spectrometry for lipid analysis

Amir Saeid Mohammadi (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; John S. Fletcher ; Per Malmberg ; Andrew G Ewing (Institutionen för kemi och molekylärbiologi ; Institutionen för kemi- och bioteknik, Analytisk kemi)
Surface and Interface Analysis: 19th International Conference on Secondary Ion Mass Spectrometry (SIMS) (0142-2421). Vol. 46 (2014), p. 379-382.
[Konferensbidrag, refereegranskat]

To provide a convenient organic matrix-free spray-on sample preparation for laser desorption ionization (LDI) that is compatible with secondary ion mass spectrometry (SIMS) imaging mass spectrometry (IMS) techniques, silver and gold nanoparticles (NPs) were applied on a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid sample. Application of Ag and Au nanoparticles to the POPC sample allowed POPC lipid fragments to be detected using NP-LDI in both positive and negative polarities. In addition, the same sample prepared for NP-LDI experiments was used for C-60 SIMS lipid analysis, and a secondary ion signal enhancement was obtained for the [M+H](+) ion of the POPC lipid as well as for characteristics POPC lipid fragments in positive ion mode.

Nyckelord: LDI mass spectrometry compatible with SIMS; Au Ag nanoparticle LDI; NPs spray-on procedure; IMS lipid analysis; Au and Ag nanoparticles



Denna post skapades 2015-01-08. Senast ändrad 2016-08-17.
CPL Pubid: 210194

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)
Institutionen för kemi och molekylärbiologi (GU)
Institutionen för kemi- och bioteknik, Analytisk kemi (2006-2014)

Ämnesområden

Fysikalisk kemi
Kemiteknik

Chalmers infrastruktur