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Enhanced bone healing around nanohydroxyapatite-coated polyetheretherketone implants: An experimental study in rabbit bone

Sargon Barkarmo ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Fredrik Currie ; Per Kjellin ; Ryo Jimbo ; Carina B. Johansson ; Victoria Franke Stenport
Journal of Biomaterials Applications (0885-3282). Vol. 29 (2014), 5, p. 737-747.
[Artikel, refereegranskad vetenskaplig]

Objective To investigate the bone response to threaded polyetheretherketone (PEEK) implants coated with nanohydroxyapatite. Materials and methods A total of 39 PEEK implants were coated with nanocrystalline hydroxyapatite and 39 uncoated implants were used as controls. The implant surface was characterized by optical interferometry and scanning electron microscope. The implants were inserted in the tibia and femur of 13 rabbits. After 6 weeks of healing, quantitative and qualitative analyses were performed. Results The test implants showed significantly higher removal torque test values compared with the control group. Histomorphometric evaluation demonstrated higher bone-to-implant contact for the test implants; however, there were no differences in bone area between the groups. Qualitative histological analyses demonstrated inflammatory cellular reactions in close vicinity of both implant surfaces. A two-cell layer of foreign body giant cells was observed irrespective of sample type. Conclusion Our findings demonstrate that implants with a threaded design render good stability to PEEK in both coated and uncoated implants. Nanohydroxyapatite-coated PEEK implants demonstrated improved bone formation compared with uncoated controls.



Denna post skapades 2015-01-07. Senast ändrad 2016-10-25.
CPL Pubid: 209856

 

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Institutioner (Chalmers)

Institutionen för odontologi (GU)
Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)
Institutionen för odontologi, sektion 2 (GU)

Ämnesområden

Biologiska vetenskaper
Materialteknik
Medicinska grundvetenskaper

Chalmers infrastruktur