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Synthesis, a case of isostructural packing, and antimicrobial activity of silver(I)quinoxaline nitrate, silver(I)(2,5-dimethylpyrazine) nitrate and two related silver aminopyridine compounds

Morsy A.M. Abu -Youssef ; Vratislav Langer (Institutionen för kemi- och bioteknik, Oorganisk miljökemi) ; Lars Öhrström (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
Dalton Transactions (1477-9226). Vol. 2006 (2006), 21, p. 2542-2550.
[Artikel, refereegranskad vetenskaplig]

The synthesis and low temperature crystal structures of [Ag(quinoxaline)]n(NO3)n, 1, [Ag(2,5-dimethylpyrazine)(NO3)]n, 2 and [Ag4(3-aminopyridine)4(NO3)4]n 3 are presented. The quinoxaline compound forms a 1D coordination polymer with the characteristic linear 2-coordination figure of silver(I), the N–Ag–N angle being 164.2(1)°, and only weak silver–nitrate interactions. In addition there is an interaction giving pairs of parallel chains as the main structural theme. The 2,5-dimethylpyrazine compound has approximately trigonal-planar coordination, also binding one nitrate at the relatively short Ag–O distances 2.444(3)Å and 2.484(3)Å, respectively, for the two crystallographically different silver atoms. This also results in a 1D coordination polymer that, despite the large differences in the Ag(I) coordination environment, is isostructural with 1. [Ag4(3-aminopyridine)4(NO3)4]n 3 forms a 2D coordination polymer by bridging nitrate ions. The antimicrobial activity of 1–3, and also of [Ag3(2-aminopyridine)4](NO3)3, 4 was screened for 13 different pathogens and substantial activity was shown for 1 against Escherichia coli and Pseudomonas aeruginosa (MIC 4 µg cm–3) and somewhat lower activity was registered against Sarcina lutea and Salmonella typhi for 1, Bordetella bronchiseptica for 2, Salmonella typhi and Pseudomonas aeruginosa for 3, and Escherichia coli and Shigella sonnie for 3 (MIC 8 µg cm–3). Only low activity was shown against the yeast Candida albicans for 1, 2 and 4 whereas no activity against this pathogen was registered for 3.

Nyckelord: X-ray structure determination, coordination, packing, antimicrobial activity



Denna post skapades 2006-08-25. Senast ändrad 2014-11-10.
CPL Pubid: 20746

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Oorganisk miljökemi (2005-2014)
Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)

Ämnesområden

Biofysikalisk kemi
Koordinationskemi

Chalmers infrastruktur