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Localized controlled drug delivery from mesoporous implants

Johan Karlsson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Necati Harmankaya ; Anders Palmquist ; R. Jimbo ; Anna Martinelli (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Gustav Sundell (Institutionen för teknisk fysik, Materialens mikrostruktur ) ; Mattias Thuvander (Institutionen för teknisk fysik, Materialens mikrostruktur ) ; Mats Halvarsson (Institutionen för teknisk fysik, Materialens mikrostruktur ) ; Pentti Tengvall ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi)
Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014. Washington, DC, United States, 15-18 June 2014 Vol. 2 (2014), p. 250-253.
[Konferensbidrag, refereegranskat]

Mesoporous materials possess both a well-defined topography on the nanometer scale, and they may serve as hosts for drugs. In this work, titanium implants coated with mesoporous TiO2 thin films have been evaluated both in vitro and in vivo. Material characterization showed that, long-range ordered mesoporous TiO2, with a pore-size of 6 nm, and a narrow pore-size distribution were obtained. An in vivo study demonstrated that the films were robust enough to withstand the implantation procedure. The in vitro apatite formation experiments showed that formation of apatite was higher on the mesoporous surface compared to its nonporous counterpart. In a separate in vivo study, two osteoporosis drugs, alendronate (ALN) and raloxifene (RLX), were immobilised into the nanoporous oxide films. The in vitro drug release tests carried out showed a sustained release of both drugs. The osteogenic response after 28 days of implantation of the drug-loaded implants showed a significantly improved bone fixation.



Denna post skapades 2014-10-15. Senast ändrad 2015-12-07.
CPL Pubid: 204312

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)
Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för biomaterialvetenskap (GU)
Institutionen för teknisk fysik, Materialens mikrostruktur (2012-2015)

Ämnesområden

Kemi

Chalmers infrastruktur