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Disposable microfluidic chip with integrated light sheet illumination enables diagnostics based on membrane vesicles

H. Deschout ; K. Raemdonck ; S. Stremersch ; P. Maoddi ; G. Mernier ; P. Renaud ; S. Jiguet ; A. Hendrix ; M. Bracke ; R. Van den Broecke ; Magnus Röding (Institutionen för matematiska vetenskaper, matematisk statistik ; SuMo Biomaterials) ; Mats Rudemo (Institutionen för matematiska vetenskaper, matematisk statistik) ; J. Demeester ; S. De Smedt ; F. Strubbe ; K. Neyts ; K. Braeckmans
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Freiburg; Germany; 27 October 2013 through 31 October 2013 Vol. 3 (2014), p. 2010-2012.
[Konferensbidrag, refereegranskat]

Cell-derived membrane vesicles that are released in body fluids are emerging as potential non-invasive biomarkers for diseases like cancer. Techniques capable of measuring the size and concentration of such membrane vesicles directly in body fluids are urgently needed. Here we report on a microfluidic chip with integrated light sheet illumination, and demonstrate accurate fluorescence Single Particle Tracking measurements of the size and concentration of membrane vesicles in cell culture medium and in interstitial fluid collected from primary human breast tumours.

Nyckelord: Diagnostics; Lab-on-a-chip; Light sheet microscopy; Single Particle Tracking



Denna post skapades 2014-10-08. Senast ändrad 2016-05-10.
CPL Pubid: 203905

 

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Institutioner (Chalmers)

Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
SuMo Biomaterials

Ämnesområden

Biokemi

Chalmers infrastruktur