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Atomically resolved tissue integration

Johan Karlsson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Gustav Sundell (Institutionen för teknisk fysik, Materialens mikrostruktur ) ; Mattias Thuvander (Institutionen för teknisk fysik, Materialens mikrostruktur ) ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi)
Nano Letters (1530-6984). Vol. 14 (2014), 8, p. 4220-4223.
[Artikel, refereegranskad vetenskaplig]

In the field of biomedical technology, a critical aspect is the ability to control and understand the integration of an implantable device in living tissue. Despite the technical advances in the development of biomaterials, the elaborate interplay encompassing materials science and biology on the atomic level is not very well understood. Within implantology, anchoring a biomaterial device into bone tissue is termed osseointegration. In the most accepted theory, osseointegration is defined as an interfacial bonding between implant and bone; however, there is lack of experimental evidence to confirm this. Here we show that atom probe tomography can be used to study the implant-tissue interaction, allowing for three-dimensional atomic mapping of the interface region. Interestingly, our analyses demonstrated that direct contact between Ca atoms and the implanted titanium oxide surface is formed without the presence of a protein interlayer, which means that a pure inorganic interface is created, hence giving experimental support to the current theory of osseointegration. We foresee that this result will be of importance in the development of future biomaterials as well as in the design of in vitro evaluation techniques.

Nyckelord: atom probe tomography , biomaterials , Biomedical implants , in vivo , nanotopography , osseointegration



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Denna post skapades 2014-09-09. Senast ändrad 2014-11-10.
CPL Pubid: 202515

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)
Institutionen för teknisk fysik, Materialens mikrostruktur (2012-2015)

Ämnesområden

Materialvetenskap
Fysik
Biologisk fysik

Chalmers infrastruktur