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Hepatic Lipogenesis and a Marker of Hepatic Lipid Oxidation, Predict Postprandial Responses of Triglyceride-rich Lipoproteins

N. Matikainen ; Martin Adiels (Institutionen för medicin, avdelningen för molekylär och klinisk medicin ; Institutionen för matematiska vetenskaper) ; S. Soderlund ; S. Stennabb ; T. Ahola ; A. Hakkarainen ; Jan Borén ; M. R. Taskinen
Obesity (1930-7381). Vol. 22 (2014), 8, p. 1854-1859.
[Artikel, refereegranskad vetenskaplig]

ObjectivePostprandial hypertriglyceridemia is an important risk factor for cardiovascular disease. The mechanisms are still unclear. Here it was tested if hepatic de novo lipogenesis (DNL) and lipid oxidation influence the postprandial responses of triglyceride-rich lipoproteins (TRL) in humans. MethodsThe contribution of hepatic DNL to hepatic TRL production was analyzed in 67 men and women with a moderate range of BMI after a fat-rich meal. Also, lipase activities, liver fat, and 3-OH-butyrate were quantitated as an indicator of -oxidation. Lipoproteins and metabolic markers were measured in fasting and postprandial blood samples. ResultsPostprandial DNL correlates with postprandial TG and apolipoprotein (apo) C-III responses in plasma and with TG, apoB48 and apoB100 responses in TRLs and their larger remnant particles. Fasting and 8-h postprandial DNL was inversely related to 3-OH-butyrate but not to liver fat content. Fasting apoC-III and 3-OH-butyrate, but not liver fat, independently predicted fasting DNL. ConclusionsThe fasting and 8-h postprandial rate of DNL was inversely associated with the hepatic lipid oxidation in humans. DNL contributes significantly to the TG content in TRLs but not to the amount of liver fat, suggesting that an imbalance between DNL and fat oxidation contributes to postprandial atherogenic dyslipidemia.

Nyckelord: DE-NOVO LIPOGENESIS, CARNITINE PALMITOYLTRANSFERASE-I, FATTY, LIVER-DISEASE, CARDIOVASCULAR-DISEASE, POSTHEPARIN PLASMA, INSULIN-RESISTANCE, LIPEMIA, MEN, HYPERTRIGLYCERIDEMIA, KETOGENESIS, Endocrinology & Metabolism, Nutrition & Dietetics



Denna post skapades 2014-09-05. Senast ändrad 2014-09-09.
CPL Pubid: 202363

 

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Institutioner (Chalmers)

Institutionen för medicin, avdelningen för molekylär och klinisk medicin (GU)
Institutionen för matematiska vetenskaperInstitutionen för matematiska vetenskaper (GU)

Ämnesområden

Endokrinologi

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