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Targeting nanoparticles across the blood-brain barrier with monoclonal antibodies

Joana A. Loureiro ; Barbara Gomes ; Manuel A. N. Coelho ; Maria do Carmo Pereira ; Sandra Rocha (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
NANOMEDICINE (1743-5889). Vol. 9 (2014), 5, p. 709-722.
[Artikel, refereegranskad vetenskaplig]

Development of therapeutics for brain disorders is one of the more difficult challenges to be overcome by the scientific community due to the inability of most molecules to cross the blood-brain barrier (BBB). Antibody-conjugated nanoparticles are drug carriers that can be used to target encapsulated drugs to the brain endothelial cells and have proven to be very promising. They significantly improve the accumulation of the drug in pathological sites and decrease the undesirable side effect of drugs in healthy tissues. We review the systems that have demonstrated promising results in crossing the BBB through receptor-mediated endocytic mechanisms for the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease.

Nyckelord: central-nervous-system, antitransferrin receptor antibody, sterically stabilized liposomes, enable drug-delivery, amyloid-beta peptide, transferrin-receptor, in-vivo, alzheimers-disease, gene-therapy, rat-brain



Denna post skapades 2014-09-03.
CPL Pubid: 202311

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)

Ämnesområden

Biologiska vetenskaper

Chalmers infrastruktur