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Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross-Linking of DNA Duplexes

D. Roeland Boer ; Lisha Wu (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Per Lincoln (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Miquel Coll
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (1433-7851). Vol. 53 (2014), 7, p. 1949-1952.
[Artikel, refereegranskad vetenskaplig]

The crystal structure of the ,enantiomer of the binuclear light-switch ruthenium complex [-(11,11-bidppz)(1,10-phenanthroline)(4)Ru-2](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves.

Nyckelord: binuclear ruthenium complexes, crystal-structure, metal-complexes, small-molecule, binding, intercalation, recognition, quadruplex, junction, promoter



Denna post skapades 2014-09-03.
CPL Pubid: 202306

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)

Ämnesområden

Kemi

Chalmers infrastruktur