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Enhancing Proteasome-Inhibitor Effect by Functionalized Gold Nanoparticles

Slvia Castro Coelho ; Sandra Rocha (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Maria Carmo Pereira ; Petras Juzenas ; Manuel A. N. Coelho
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (1550-7033). Vol. 10 (2014), 4, p. 717-723.
[Artikel, refereegranskad vetenskaplig]

Colloidal gold nanoparticles intensify the anticancer response of the drug bortezomib, a proteasome inhibitor. Polyethylene glycol-coated gold nanoparticles and the drug show a synergistic effect in reducing the cell viability of prostate cancer cell line Du145. It was observed a significant cell viability reduction with bortezomib concentrations as low as 4 nM. The proteasome inhibitor alone had to be present at concentrations in the ranger of 120 nM to induce identical cytotoxicity response. These findings demonstrate that gold nanoparticles enhancing the permeation and retention (EPR) effect in Du145 cells and open the possibility to decrease multi-drug resistance (MDR). The in vitro results of functionalized gold nanoparticles, internalized by cancer cells, pave the way for a more efficient proteasome inhibitor delivery and release in adenocarcinoma cells.

Nyckelord: prostate-cancer, radiation-therapy, cells, brachytherapy, bortezomib, carcinoma, size

Denna post skapades 2014-09-03.
CPL Pubid: 202287


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)



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