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Localized mRNA translation and protein association

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Central European Journal of Physics (1895-1082). Vol. 12 (2014), 8, p. 603-609.
[Artikel, refereegranskad vetenskaplig]

Recent direct observations of localization of mRNAs and proteins both in prokaryotic and eukaryotic cells can be related to slowdown of diffusion of these species due to macromolecular crowding and their ability to aggregate and form immobile or slowly mobile complexes. Here, a generic kinetic model describing both these factors is presented and comprehensively analyzed. Although the model is non-linear, an accurate self-consistent analytical solution of the corresponding reaction-diffusion equation has been constructed, the types of localized protein distributions have been explicitly shown, and the predicted kinetic regimes of gene expression have been classified.

Nyckelord: subcellular processes, gene transcription, mRNA translation, protein diffusion, association and degradation



Denna post skapades 2014-08-29.
CPL Pubid: 202098

 

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Institutioner (Chalmers)

Institutionen för teknisk fysik, Kemisk fysik (1900-2015)

Ämnesområden

Fysikalisk kemi
Teknisk fysik

Chalmers infrastruktur