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**Harvard**

Gennemark, P., Nordlander, B., Hohmann, S. och Wedelin, D. (2006) * A simple mathematical model of adaptation to high osmolarity in yeast*.

** BibTeX **

@article{

Gennemark2006,

author={Gennemark, Peter and Nordlander, Bodil and Hohmann, Stefan and Wedelin, Dag},

title={ A simple mathematical model of adaptation to high osmolarity in yeast},

journal={In silico biology},

issn={ISSN 1434-3207},

volume={6},

issue={0018 },

abstract={We present a simple ordinary differential equation (ODE) model of the adaptive response to an osmotic shock in the yeast Saccharomyces cerevisiae. The model consists of two main components. First, a biophysical model describing how the cell volume and the turgor pressure are affected by varying extra-cellular osmolarity. The second component describes how the cell controls the biophysical system in order to keep turgor pressure, or equivalently volume, constant. This is done by adjusting the glycerol production and the glycerol outflow from the cell. The complete model consists of 4 ODEs, 3 algebraic equations and 10 parameters. The parameters are constrained from various literature sources and estimated from new and previously published absolute time series data on intra-cellular and total glycerol. The qualitative behaviour of the model has been successfully tested on data from other genetically modified strains as well as data for different input signals. Compared to a previous detailed model of osmoregulation, the main strength of our model is its lower complexity, contributing to a better understanding of osmoregulation by focusing on relationships which are obscured in the more detailed model. Besides, the low complexity makes it possible to obtain more reliable parameter estimates.},

year={2006},

keywords={Saccharomyces cerevisiae, osmotic shock, HOG pathway, Fps1, ODEs, model complexity},

}

** RefWorks **

RT Journal Article

SR Electronic

ID 20145

A1 Gennemark, Peter

A1 Nordlander, Bodil

A1 Hohmann, Stefan

A1 Wedelin, Dag

T1 A simple mathematical model of adaptation to high osmolarity in yeast

YR 2006

JF In silico biology

SN ISSN 1434-3207

VO 6

IS 0018

AB We present a simple ordinary differential equation (ODE) model of the adaptive response to an osmotic shock in the yeast Saccharomyces cerevisiae. The model consists of two main components. First, a biophysical model describing how the cell volume and the turgor pressure are affected by varying extra-cellular osmolarity. The second component describes how the cell controls the biophysical system in order to keep turgor pressure, or equivalently volume, constant. This is done by adjusting the glycerol production and the glycerol outflow from the cell. The complete model consists of 4 ODEs, 3 algebraic equations and 10 parameters. The parameters are constrained from various literature sources and estimated from new and previously published absolute time series data on intra-cellular and total glycerol. The qualitative behaviour of the model has been successfully tested on data from other genetically modified strains as well as data for different input signals. Compared to a previous detailed model of osmoregulation, the main strength of our model is its lower complexity, contributing to a better understanding of osmoregulation by focusing on relationships which are obscured in the more detailed model. Besides, the low complexity makes it possible to obtain more reliable parameter estimates.

LA eng

LK http://www.bioinfo.de/isb/2006/06/0018/

OL 30