CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro

Giuseppe Maria de Peppo ; Hossein Agheli ; Camilla Karlsson ; Karin Ekström ; Helena Brisby ; Maria Lennerås ; Stefan Gustafsson (Institutionen för teknisk fysik, Eva Olsson Group ; SuMo Biomaterials) ; Peter Sjövall (Institutionen för teknisk fysik, Biologisk fysik) ; Anna Johansson ; Eva Olsson (Institutionen för teknisk fysik, Eva Olsson Group ) ; J. Lausmaa ; Peter Thomsen ; S. Petronis
International Journal of Nanomedicine (1176-9114). Vol. 9 (2014), 1, p. 2499-2515.
[Artikel, refereegranskad vetenskaplig]

Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Results: We found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.

Nyckelord: colloidal lithography; nanotopography; human mesenchymal stem cells; cell proliferation; osteogenic differentiation; mineralization; implantable materials



Denna post skapades 2014-06-23. Senast ändrad 2016-03-21.
CPL Pubid: 199477

 

Läs direkt!


Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för biomaterialvetenskap (GU)
Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för ortopedi (GU)
Institutionen för teknisk fysik, Eva Olsson Group (2012-2015)
SuMo Biomaterials
Institutionen för teknisk fysik, Biologisk fysik (2007-2015)

Ämnesområden

Biomaterialvetenskap

Chalmers infrastruktur