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Multivariate evaluation of doxorubicin surface-enhanced Raman spectra.

Charlotte Eliasson (Institutionen för kemi och biovetenskap) ; Anders Lorén (Institutionen för kemi och biovetenskap, Analytisk och marin kemi) ; K V Murty ; M Josefson ; Mikael Käll ; Jonas Abrahamsson ; Katarina Abrahamsson
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (1386-1425). Vol. 57 (2001), 9, p. 1907-15.
[Artikel, refereegranskad vetenskaplig]

Multivariate evaluation of surface-enhanced Raman spectra of doxorubicin in plasma was performed. In a principal component analysis (PCA) all spectral features were modelled into three principal components. The major variation of the data was shown to be the variation of doxorubicin Raman signal together with the doxorubicin fluorescence, whereas the variation due to plasma was of minor importance. It was also shown that the surface-enhanced Raman scattering (SERS) measurements were independent on such factors as measurement occasion and silver colloids. The presented results show that with some improvements, quantification of doxorubicin directly in plasma could be possible.

Nyckelord: Animals, Antibiotics, Antineoplastic, blood, chemistry, Cattle, Doxorubicin, blood, chemistry, Multivariate Analysis, Plasma, chemistry, Principal Component Analysis, Signal Processing, Computer-Assisted, Spectrum Analysis, Raman



Denna post skapades 2014-04-26.
CPL Pubid: 197177

 

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Institutioner (Chalmers)

Institutionen för kemi och biovetenskap (1900-2005)
Institutionen för kemi och biovetenskap, Analytisk och marin kemi (1900-2004)
Institutionen för fysik (GU) (GU)
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik (1991-2005)
Institutionen för kemi (2001-2011)

Ämnesområden

Kemi

Chalmers infrastruktur