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Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

L. Fagerberg ; B. M. Hallstrom ; P. Oksvold ; C. Kampf ; D. Djureinovic ; J. Odeberg ; M. Habuka ; S. Tahmasebpoor ; A. Danielsson ; K. Edlund ; A. Asplund ; E. Sjostedt ; E. Lundberg ; C. A. Szigyarto ; M. Skogs ; J. O. Takanen ; H. Berling ; H. Tegel ; J. Mulder ; P. Nilsson ; J. M. Schwenk ; C. Lindskog ; F. Danielsson ; Adil Mardinoglu (Institutionen för kemi- och bioteknik, Systembiologi) ; A. Sivertsson ; K. von Feilitzen ; M. Forsberg ; M. Zwahlen ; I. Olsson ; S. Navani ; M. Huss ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi) ; F. Ponten ; M. Uhlen
Molecular & Cellular Proteomics (1535-9476). Vol. 13 (2014), 2, p. 397-406.
[Artikel, refereegranskad vetenskaplig]

Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody-based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to approximate to 80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.



Denna post skapades 2014-04-10. Senast ändrad 2014-10-27.
CPL Pubid: 196549

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)

Ämnesområden

Kemi

Chalmers infrastruktur