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Polypeptide Multilayer Self-Assembly Studied by Ellipsometry

Marina Craig (Institutionen för kemi- och bioteknik ; SuMo Biomaterials) ; Krister Holmberg (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; E. Le Ru ; P. Etchegoin
Journal of Drug Delivery (2090-3014). Vol. 2014 (2014), p. (article ID) 424697.
[Artikel, refereegranskad vetenskaplig]

A polypeptide nanofilm made by layer-by-layer (LbL) self-assembly was built on a surface that mimics nonwoven, a material commonly used in wound dressings. Poly-L-lysine (PLL) and poly-L-glutamic acid (PLGA) are the building blocks of the nanofilm, which is intended as an enzymatically degradable lid for release of bactericides to chronic wounds. Chronic wounds often carry infection originating from bacteria such as Staphylococcus aureus and a release system triggered by the degree of infection is of interest. The dry nanofilm was studied with ellipsometry. The thickness of the nanofilm was 60% less in its dry state than in its wet state. The measurements showed that a primer was not necessary to build a stable nanofilm, which is practically important in our case because a nondegradable primer is highly unwanted in a wound care dressing. Added V8 (glutamyl endopeptidase) enzymes only showed adsorption on the nanofilm at room temperature, indicating that the PLL/PLGA “lid” may remain intact until the dressing has been filled with wound exudate at the elevated temperature typical of that of the wound.



Denna post skapades 2014-02-17. Senast ändrad 2016-03-21.
CPL Pubid: 193865

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik (2005-2014)
SuMo Biomaterials
Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)

Ämnesområden

Kemi

Chalmers infrastruktur

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