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Electrospun nanofibrous cellulose scaffolds with controlled microarchitecture

K. Rodriguez ; Johan Sundberg (Institutionen för kemi- och bioteknik, Polymerteknologi) ; Paul Gatenholm (Institutionen för kemi- och bioteknik, Polymerteknologi) ; S. Renneckar
Carbohydrate Polymers (0144-8617). Vol. 100 (2014), p. 143-149.
[Artikel, refereegranskad vetenskaplig]

Introducing porosity in electrospun scaffolds is critical to improve cell penetration and nutrient diffusion for tissue engineering. Nanofibrous cellulose scaffolds were prepared by electrospinning cellulose acetate (CA) followed by saponification to regenerate cellulose. Using a computer-assisted design approach, scaffolds underwent laser ablation resulting in pores with diameters between 50 and 300 mu m. without damaging or modifying the surrounding scaffold area. A new mineralization method was employed in conjunction with microablation using commercial phosphate buffered saline (PBS) to soak carboxymethylcellulose surface-modified electrospun scaffolds. The resulting crystals within the scaffold on the interior of the pore had a calcium to phosphate ratio of 1.56, similar to hydroxyapatite. It was observed that porosity of the cellulose scaffolds enhanced osteoblast cell attachment at the edge of the pores, while mineralization enhanced overall cell density.

Nyckelord: Cellulose, Scaffold, Porosity, Hydroxyapatite, Bone regeneration, Laser, TISSUE ENGINEERING APPLICATIONS, CALCIUM-PHOSPHATE, AFFINITY MEMBRANE, HYDROXYAPATITE, SURFACE, DESIGN, ARCHITECTURE, CONSTRUCTS, PEPTIDES, ADHESION, SNER AS, 1975, ACCOUNTS OF CHEMICAL RESEARCH, V8, P273



Denna post skapades 2014-02-13. Senast ändrad 2014-02-17.
CPL Pubid: 193766

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Polymerteknologi (2005-2014)

Ämnesområden

Polymerteknologi

Chalmers infrastruktur