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The Effect of Hydroxyapatite Nanocrystals on Osseointegration of Titanium Implants: An In Vivo Rabbit Study

Karin Breding (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Ryo Jimbo ; M. Hayashi ; Y. Xue ; K. Mustafa ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi)
International Journal of Dentistry (1687-8728). Vol. 2014 (2014), p. (article id) 171305.
[Artikel, refereegranskad vetenskaplig]

Osseointegration is dependent on implant surface characteristics, including surface chemistry and topography. The presence of nanosized calcium phosphates on the implant surface is interesting to investigate since they affect both the nanotopography and surface chemistry, forming a bone mineral resembling surface. In this work, the osseointegration of titanium implants with and without the presence of hydroxyapatite (HA) nanocrystals has been evaluated in vivo. The integration was examined using removal torque measurements and real-time polymerase chain reaction (RT-PCR) analysis. The study was performed using two healing time points, 3 and 12 weeks. The results showed that the torque needed to remove the implants was insignificant between the non- and HA-coated implants, both at weeks 3 and 12. The RT-PCR, however, showed significant differences for osteoblast, osteoclast, and proinflammation markers when HA nanocrystals were present.



Denna post skapades 2014-01-27. Senast ändrad 2016-10-27.
CPL Pubid: 193129

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)

Ämnesområden

Kemi

Chalmers infrastruktur