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Preparation of Porous Poly(3-Hydroxybutyrate) Films by Water-Droplet Templating

Anna Bergstrand (Institutionen för kemi- och bioteknik ; SuMo Biomaterials) ; Helene Andersson ; Johanna Cramby (Institutionen för kemi- och bioteknik) ; Kristin Sott ; Anette Larsson (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi ; SuMo Biomaterials)
Journal of Biomaterials and Nanobiotechnology (2158-7027). Vol. 3 (2012),
[Artikel, refereegranskad vetenskaplig]

Porous resorbable implants are of great interest since they may deliver bioactives or drug s, facilitate the transport of body fluids or degradation products and provide a favorable environment for cell attachment and growth. In this work we report on a method using concentrated emulsions to template interconnected solid foam materials and to produce highly porous poly(3-hydroxybutyrate) (PHB) materials. Porous PHB films were cast made from water-in-oil template emulsions including Span 80 and lithium sulphate. The films were characterized by SEM-EDX and DMA. The water uptake of the films was recorded in orde r to determine the fraction water available pores. The results show that the ad- dition of lithium sulphate allows a fine tuning of the film morphology with respect to porosity and interconnected po- rous structure. The film porosity was determined to 51% ± 3%, 52% ± 3% and 45% ± 3% for the films made with 0%, 2.9% and 14.3% lithium sulphate in the template emulsion , respectively. The fraction water available pores was sig- nificantly lower, 11% ±3%, 38% ±12% and 48% ± 7% for films with 0%, 2.9% and 14.3% litium sulphate respectively. Differences in fraction water available pores and total porosity for the films reflects the film morphology and differ- ences in pore interconnection.

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Denna post skapades 2014-01-14. Senast ändrad 2016-11-02.
CPL Pubid: 192425


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik (2005-2014)
SuMo Biomaterials
Institutionen för kemi- och bioteknik, Farmaceutisk teknologi (2005-2014)


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Chalmers infrastruktur