CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Maternal beef and postweaning herring diets increase bone mineral density and strength in mouse offspring.

Ays Hussain ; Hanna Olausson ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Intawat Nookaew (Institutionen för kemi- och bioteknik, Systembiologi) ; Sakda Khoomrung (Institutionen för kemi- och bioteknik, Systembiologi) ; Louise Andersson ; Antti Koskela ; Juha Tuukkanen ; Claes Ohlsson ; Agneta Holmäng
Experimental biology and medicine (Maywood, N.J.) (1535-3699). Vol. 238 (2013), 12, p. 1362-9.
[Artikel, refereegranskad vetenskaplig]

The maternal diet during gestation and lactation affects the long-term health of the offspring. We sought to determine whether maternal and postweaning crossover isocaloric diets based on fish or meat affect the geometry, mineral density, and biomechanical properties of bone in mouse offspring in adulthood. During gestation and lactation, C57BL/6 dams were fed a herring- or beef-based diet. After weaning, half of the pups in each group were fed the same diet as their dams, and half were fed the other diet. Areal bone mineral density (aBMD) and bone mineral content (BMC) of the whole body and lumbar spine were measured in the offspring by dual X-ray absorptiometry at 9 and 21 weeks of age. At 22-26 weeks, tibia bone geometry (length, cortical volumetric (v) BMD, BMC, area and thickness) was analyzed by peripheral quantitative computed tomography, and the biomechanical properties of the tibia were analyzed by the three-point bending test. Plasma insulin-like growth factor-1 was analyzed at 12 weeks. In comparison to the maternal herring diet, the maternal beef diet increased aBMD and BMC in the whole body and lumbar spine of adult offspring, as well as cortical vBMD, BMC, bone area, and thickness at the mid-diaphyseal region of the tibia and the biomechanical properties of tibia strength. In contrast, a postweaning beef diet decreased aBMD in the lumbar spine and BMC in the whole body and lumbar spine compared with a postweaning herring diet, which instead increased plasma insulin-like growth factor-1 levels. The change from a maternal beef diet before weaning to a herring diet after weaning decreased body weight and increased the cortical area, vBMD, BMC, thickness, and strength of the tibia. These significant crossover effects indicate that a preweaning maternal beef diet and a postweaning herring diet are optimal for increasing BMC and bone strength in offspring in adulthood.

Denna post skapades 2013-12-23. Senast ändrad 2015-01-16.
CPL Pubid: 190446


Läs direkt!

Länk till annan sajt (kan kräva inloggning)

Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi (GU)
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)
Centre for Bone and Arthritis Research (GU)



Chalmers infrastruktur