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Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy

Lenka Novakova ; Bengt Skoog ; Björn Runmarker ; Sven Ekholm ; Stefan Winblad ; Vera Lisovskaja (Institutionen för matematiska vetenskaper, matematisk statistik) ; Oluf Andersen
Multiple sclerosis journal (1352-4585). Vol. 20 (2014), 4, p. 496-500.
[Artikel, refereegranskad vetenskaplig]

The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the "CIS only" condition. The study was based on the longitudinally followed Gothenburg 1950-1964 incidence cohort (n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained "CIS only". Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining "CIS only". Patients who had experienced no relapse during the first 25 years remained "CIS only" for the subsequent 25 years of follow-up.

Nyckelord: Clinically isolated syndrome; multiple sclerosis; cohort; optic neuritis; neuropsychology; magnetic resonance imaging



Denna post skapades 2013-11-26. Senast ändrad 2014-07-22.
CPL Pubid: 187476

 

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Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (2006-2016)
Psykologiska institutionen (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)

Ämnesområden

Klinisk medicin

Chalmers infrastruktur