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Charged microcapsules for controlled release of hydrophobic actives Part II: Surface modification by LbL adsorption and lipid bilayer formation on properly anchored dispersant layers

Markus Andersson Trojer (Institutionen för kemi- och bioteknik, Teknisk ytkemi ; SuMo Biomaterials) ; Ye Li (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Maria Wallin (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Krister Holmberg (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Magnus Nydén (Institutionen för kemi- och bioteknik, Teknisk ytkemi ; SuMo Biomaterials)
Journal of Colloid and Interface Science (0021-9797). Vol. 409 (2013), p. 8-17.
[Artikel, refereegranskad vetenskaplig]

Charge microcapsules with a dodecane core and a poly(methyl methacrylate) (PMMA) shell have been prepared via the internal phase separation method using ionic dispersants. The microcapsules have subsequently been surface modified with polyelectrolyte multilayers and lipid bilayers. Two types of ionic dispersant systems have been investigated: a small set of ionic amphiphilic block copolymers of poly(methyl methacrylate)-block-poly(sodium (meth)acrylate) type and an oil-soluble anionic surfactant, sodium 1,5-dioxo-1,5-bis(3,5,5-trimethylhexyloxy)-3((3,5,5trimethylhexyloxy)car bonyl)pentane-2-sulfonate, in combination with a water-soluble polycation, poly(diallyldimethylammonium chloride). The Layer-by-Layer adsorption of the polyelectrolyte pair poly(diallydimethylammonium chloride) (350,000 g/mol) and poly(sodium methacrylate) (15,000 g/mol) was successfully made on both microcapsule systems with the formation of very thin multilayers as indicated with quartz crystal microbalance with dissipation monitoring (QCM-D) measurements on model surfaces. Formation of a lipid bilayer on the surface of the microcapsules from liposomes with a charge opposite that of the capsule surface was also proven to be successful as indicated by the C-potential of the microcapsules, the characteristic frequency shift as measured with QCM-D and fluorescence recovery after photobleaching (FRAP) on model systems. However, the proper anchorage of the dispersants in the underlying PMMA surface was key for the successful surface modification.

Nyckelord: Quartz crystal microbalance with dissipation monitoring, Core-shell particle, Lipid vesicle, Liposome, polyelectrolyte multilayer capsules, internal phase-separation, colloidal particles, vesicle adsorption, electrostatic interactions, shell microcapsules, emulsion droplets, sustained-release, diffusion, encapsulation

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Denna post skapades 2013-10-28. Senast ändrad 2016-10-25.
CPL Pubid: 185724


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)
SuMo Biomaterials


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