CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics

Cecilia Larsson Wexell ; Peter Thomsen ; Björn-Owe Aronsson (Institutionen för teknisk fysik, Kemisk fysik) ; Pentti Tengvall ; Michael Rodahl (Institutionen för teknisk fysik) ; Jukka Lausmaa ; Bengt Kasemo (Institutionen för teknisk fysik, Kemisk fysik) ; Lars Ericson
International Journal of Biomaterials (1687-8787). Vol. 2013 (2013), p. Art. no. 412482.
[Artikel, refereegranskad vetenskaplig]

In a series of experimental studies, the bone formation around systematically modified titanium implants is analyzed. In the present study, three different surface modifications were prepared and evaluated. Glow-discharge cleaning and oxidizing resulted in a highly stoichiometric TiO2 surface, while a glow-discharge treatment in nitrogen gas resulted in implants with essentially a surface of titanium nitride, covered with a very thin titanium oxide. Finally, hydrogen peroxide treatment of implants resulted in an almost stoichiometric TiO2, rich in hydroxyl groups on the surface. Machined commercially pure titanium implants served as controls. Scanning Auger Electron Spectroscopy, Scanning Electron Microscopy, and Atomic Force Microscopy revealed no significant differences in oxide thickness or surface roughness parameters, but differences in the surface chemical composition and apparent topography were observed. After surface preparation, the implants were inserted in cortical bone of rabbits and evaluated after 1, 3, and 6 weeks. Light microscopic evaluation of the tissue response showed that all implants were in contact with bone and had a large proportion of newly formed bone within the threads after 6 weeks. There were no morphological differences between the four groups. Our study shows that a high degree of bone contact and bone formation can be achieved with titanium implants of different surface composition and topography.



Denna post skapades 2013-10-18. Senast ändrad 2016-10-17.
CPL Pubid: 185383

 

Läs direkt!

Lokal fulltext (fritt tillgänglig)

Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för biomaterialvetenskap (GU)
Institutionen för teknisk fysik, Kemisk fysik (1900-2015)
Institutionen för teknisk fysik (1900-2015)
Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi (GU)

Ämnesområden

Klinisk medicin

Chalmers infrastruktur