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Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITP.

Margareta Jernås ; Yu Hou ; Frida Strömberg Célind ; Linlin Shao ; Intawat Nookaew (Institutionen för kemi- och bioteknik, Systembiologi) ; Qian Wang ; Xiuli Ju ; Karin Mellgren ; Hans Wadenvik ; Ming Hou ; Bob Olsson
Blood (1528-0020). Vol. 122 (2013), 10, p. 1789-92.
[Artikel, refereegranskad vetenskaplig]

Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves, but in some it becomes chronic. To investigate whether these 2 phases of the disease are molecularly similar or separate entities we performed DNA microarray analysis (GEO accession number: GSE46922) of T-cells from newly diagnosed children and children with chronic ITP. We found complete separation of the gene expression profiles between the 2 phases of the disease. Furthermore, the gene expression levels of several cytokines differed between the 2 phases of the disease. This was also reflected in plasma with increased levels of interleukin (IL)-16 and TNF-related weak inducer of apoptosis and lower levels of IL-4 in newly diagnosed compared with chronic ITP. Thus, our data indicate that chronic ITP in childhood is a separate disease entity, dissimilar in many aspects to the newly diagnosed phase.

Denna post skapades 2013-09-24. Senast ändrad 2013-11-07.
CPL Pubid: 183914


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Institutioner (Chalmers)

Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (GU)
Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (GU)



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