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Is the Gly82Ser polymorphism in the RAGE gene relevant to schizophrenia and the personality trait psychoticism?

Petra Suchankova ; Jonas Klang ; Carin Cavanna ; Göran Holm ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Erik G Jönsson ; Agneta Ekman
Journal of psychiatry & neuroscience : JPN (1488-2434). Vol. 37 (2012), 2, p. 122-128.
[Artikel, refereegranskad vetenskaplig]

The receptor for advanced glycation end products (RAGE) is the main receptor for S100B, an astrogial proinflammatory mediator that has been suggested to be involved in the pathophysiology of schizophrenia. To further elucidate the possible relevance of inflammation for mental functions, we investigated a functional polymorphism in the gene coding for RAGE in relation to personality traits and susceptibility to schizophrenia.

Nyckelord: Case-Control Studies, Cohort Studies, DNA, genetics, Female, Genotype, Humans, Male, Middle Aged, Nerve Growth Factors, genetics, Personality, genetics, Personality Tests, Polymorphism, Genetic, Polymorphism, Single Nucleotide, Psychotic Disorders, psychology, Receptors, Immunologic, genetics, S100 Proteins, genetics, Schizophrenia, genetics, Schizophrenic Psychology



Denna post skapades 2013-08-14. Senast ändrad 2016-06-29.
CPL Pubid: 181364

 

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Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi (GU)
Institutionen för medicin (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)

Ämnesområden

Farmakologi

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