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Measuring absolute nanoparticle number concentrations from particle count time series

Magnus Röding (Institutionen för matematiska vetenskaper, matematisk statistik ; SuMo Biomaterials) ; H. Deschout ; K. Braeckmans ; Mats Rudemo (Institutionen för matematiska vetenskaper, matematisk statistik)
Journal of Microscopy (0022-2720). Vol. 251 (2013), 1, p. 19-26.
[Artikel, refereegranskad vetenskaplig]

Single-particle microscopy is important for characterization of nanoparticulate matter for which accurate concentration measurements are crucial. We introduce a method for estimating absolute number concentrations in nanoparticle dispersions based on a fluctuating time series of particle counts, known as a Smoluchowski process. Thus, unambiguous tracking of particles is not required and identification of single particles is sufficient. However, the diffusion coefficient of the particles must be estimated separately. The proposed method does not require precalibration of the detection region volume, as this can be estimated directly from the observations. We evaluate the method in a simulation study and on experimental data from a series of dilutions of 0.2- and 0.5-m polymer nanospheres in water, obtaining very good agreement with reference values.

Nyckelord: Concentration measurements, fluorescence microscopy, single-particle methods, Smoluchowski, size, fluctuations, interface, delivery, physics

Denna post skapades 2013-07-18. Senast ändrad 2017-01-27.
CPL Pubid: 180206


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Institutioner (Chalmers)

Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
SuMo Biomaterials



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