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Protrusive growth and periodic contractile motion in surface-adhered vesicles induced by Ca2+-gradients

Tatsiana Lobovkina (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Irep Gözen (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Yavuz Erkan (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Jessica Olofsson (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; S. G. Weber ; Owe Orwar (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
Soft Matter (1744-683X). Vol. 6 (2010), 2, p. 268-272.
[Artikel, refereegranskad vetenskaplig]

Local signaling, cell polarization, and protrusive growth are key steps in directed migration of biological cells guided by chemical gradients. Here we present a minimal system which captures several key features of cellular migration from signaling-to-motion. The model system consists of flat, negatively charged phospholipid vesicles, a negatively charged surface, and a local, and controllable point-source supply of calcium ions. In the presence of a Ca2+ gradient, the surface-adhered vesicles form protrusions in the direction of the gradient. We also observe membrane shape oscillations between expanded (flattened), and spherical states as a function of the Ca2+-concentration. The observed phenomena can be of importance in explaining motile action in prebiotic, primitive, and biomimetic systems, as well as in development of novel soft-matter nano-and microscale mechanical devices.

Nyckelord: bilayer-membranes, lipid nanotubes, networks, phosphatidylserine, chemotaxis, liposomes, cells, curvature, calcium, tension

Denna post skapades 2013-07-09.
CPL Pubid: 180025


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)



Chalmers infrastruktur