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A Whole-Grain-Rich Diet Reduces Urinary Excretion of Markers of Protein Catabolism and Gut Microbiota Metabolism in Healthy Men after One Week

Alastair Ross (Institutionen för kemi- och bioteknik, Livsmedelsvetenskap) ; E. Pere-Trepat ; I. Montoliu ; F. P. J. Martin ; S. Collino ; S. Moco ; J. P. Godin ; M. Cleroux ; P. A. Guy ; I. Breton ; R. Bibiloni ; A. Thorimbert ; I. Tavazzi ; L. Tornier ; A. Bebuis ; S. J. Bruce ; M. Beaumont ; L. B. Fay ; S. Kochhar
Journal of Nutrition (0022-3166). Vol. 143 (2013), 6, p. 766-773.
[Artikel, refereegranskad vetenskaplig]

Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may be beneficial for health remain speculative. In an exploratory, randomized, researcher-blinded, crossover trial, we measured metabolic profile differences between healthy participants eating a diet based on WGs compared with a diet based on RGs. Seventeen healthy adult participants (11 female, 6 male) consumed a controlled diet based on either WG-rich or RG-rich foods for 2 wk, followed by the other diet after a 5-wk washout period. Both diets were the same except for the use of WG (150 g/d) or FIG foods. The metabolic profiles of plasma, urine, and fecal water were measured using H-1-nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry (plasma only). After 1 wk of intervention, the WG diet led to decreases in urinary excretion of metabolites related to protein catabolism (urea, methylguanadine), lipid (carnitine and acylcarnitines) and gut microbial (4-hydroxyphenylacetate, trimethylacetate, dimethylacetate) metabolism in men compared with the same time point during the FIG intervention. There were no differences between the interventions after 2 wk. Urinary urea, carnitine, and acylcarnitine were lower at wk 1 of the WG intervention relative to the FIG intervention in all participants. Fecal water short-chain fatty acids acetate and butyrate were relatively greater after the WG diet compared to the RG diet. Although based on a small population and for a short time period, these observations suggest that a WG diet may affect protein metabolism.

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Denna post skapades 2013-07-04. Senast ändrad 2014-10-31.
CPL Pubid: 179802


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Institutionen för kemi- och bioteknik, Livsmedelsvetenskap (2005-2014)



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