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Empirical to mechanistic modelling in high shear granulation

Ingela Niklasson Björn ; Anders Jansson (Institutionen för kemi- och bioteknik, Kemisk apparatteknik) ; Magnus Karlsson ; Staffan Folestad ; Anders Rasmuson (Institutionen för kemi- och bioteknik, Kemisk apparatteknik)
Chemical Engineering Science Vol. 60 (2005), p. 3795-3803.
[Artikel, refereegranskad vetenskaplig]

This paper gives an overview of the different models available for granulation in high shear mixers with a focus on applicability in the pharmaceutical industry. Three examples of applications are given. The examples indicate the potential of mechanistically based models for scale-up and the importance of understanding the dynamics of the granulation process. The first two examples show how the impeller torque can be modelled and predicted in the dry and wet mixing phases of the high shear granulation process, using a solid mechanics and a hierarchical multivariate model, respectively. In the third application the particle size distribution is modelled using population balances and it is shown how different operating conditions can be included in the coalescence kernel to describe the granule growth.

Nyckelord: Agglomeration, Granulation, Population balance, Multivariate modelling, Scale-up, Solid mechanics



Denna post skapades 2006-08-25. Senast ändrad 2015-12-17.
CPL Pubid: 17898

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Kemisk apparatteknik (2005-2014)

Ämnesområden

Annan kemiteknik

Chalmers infrastruktur