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Glycoprotein 130 promotes human blastocyst development in vitro

F. Hambiliki ; Jörg Hanrieder (Institutionen för kemi- och bioteknik, Analytisk kemi) ; J. Bergquist ; J. Hreinsson ; A. Stavreus-Evers ; K. Wanggren
Fertility and Sterility (0015-0282). Vol. 99 (2013), 6, p. 1592-U444.
[Artikel, refereegranskad vetenskaplig]

Objective: To investigate the efficacy of leukemia inhibitory factor (LIF) and/or glycoprotein 130 Design: Laboratory study. Setting: University hospital-based IVF clinic. Patient(s): A total of 164 frozen embryos that survived thawing were cultured in media supplemented Intervention(s): Morphological development was evaluated by light microscopy. Protein expression Main Outcome Measure(s): Embryo development and protein content. Result(s): Addition of gp130 to culture media improved blastocyst formation (73% vs. 43%). Addition of Conclusion(s): Glycoprotein 130, but not LIF, seems to be beneficial for preimplantation embryo

Nyckelord: Blastocyst, LIF, gp130, MALDI-TOF MS, ICMS

Denna post skapades 2013-06-17.
CPL Pubid: 178587


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Analytisk kemi (2006-2014)


Obstetrik och kvinnosjukdomar

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