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Bridging Ligand Length Controls AT Selectivity and Enantioselectivity of Binuclear Ruthenium Threading Intercalators

Johan Johansson (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Y. B. Wang ; Mattias P. Eng ; Nina Kann (Institutionen för kemi- och bioteknik, Organisk kemi) ; Per Lincoln (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Johanna Andersson (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
Chemistry-a European Journal (0947-6539). Vol. 19 (2013), 20, p. 6246-6256.
[Artikel, refereegranskad vetenskaplig]

The slow dissociation of DNA threading intercalators makes them interesting as model compounds in the search for new DNA targeting drugs, as there appears to be a correlation between slow dissociation and biological activity. Thus, it would be of great value to understand the mechanisms controlling threading intercalation, and for this purpose we have investigated how the length of the bridging ligand of binuclear ruthenium threading intercalators affects their DNA binding properties. We have synthesised a new binuclear ruthenium threading intercalator with slower dissociation kinetics from ct-DNA than has ever been observed for any ruthenium complex with any type of DNA, a property that we attribute to the increased distance between the ruthenium centres of the new complex. By comparison with previously studied ruthenium complexes, we further conclude that elongation of the bridging ligand reduces the sensitivity of the threading interaction to DNA flexibility, resulting in a decreased AT selectivity for the new complex. We also find that the length of the bridging ligand affects the enantioselectivity with increasing preference for the enantiomer as the bridging ligand becomes longer.

Nyckelord: DNA, intercalation, kinetics, ruthenium, sequence selectivity



Denna post skapades 2013-06-17. Senast ändrad 2016-10-03.
CPL Pubid: 178584

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)
Institutionen för fysik (GU) (GU)
Institutionen för kemi- och bioteknik, Organisk kemi (2006-2014)

Ämnesområden

Fysikalisk kemi

Chalmers infrastruktur