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Toward systems metabolic engineering of Aspergillus and Pichia species for the production of chemicals and biofuels

Luis Caspeta (Institutionen för kemi- och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Biotechnology Journal (1860-6768). Vol. 8 (2013), 5, p. 534-544.
[Artikel, refereegranskad vetenskaplig]

Recently genome sequence data have become available for Aspergillus and Pichia species of industrial interest. This has stimulated the use of systems biology approaches for large-scale analysis of the molecular and metabolic responses of Aspergillus and Pichia under defined conditions, which has resulted in much new biological information. Case-specific contextualization of this information has been performed using comparative and functional genomic tools. Genomics data are also the basis for constructing genome-scale metabolic models, and these models have helped in the contextualization of knowledge on the fundamental biology of Aspergillus and Pichia species. Furthermore, with the availability of these models, the engineering of Aspergillus and Pichia is moving from traditional approaches, such as random mutagenesis, to a systems metabolic engineering approach. Here we review the recent trends in systems biology of Aspergillus and Pichia species, highlighting the relevance of these developments for systems metabolic engineering of these organisms for the production of hydrolytic enzymes, biofuels and chemicals from biomass.

Nyckelord: Aspergillus and Pichia species, Contextualization, Genome-scale metabolic models (GEMs), High-throughput, Systems metabolic engineering

Published in BIOTECHNOLOGY JOURNAL Volume: 8 Issue: 5 Special Issue: SI

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Denna post skapades 2013-06-10. Senast ändrad 2014-10-27.
CPL Pubid: 178101


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)


Hållbar utveckling
Biokemi och molekylärbiologi

Chalmers infrastruktur



Denna publikation är ett resultat av följande projekt:

Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO) (EC/FP7/247013)