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Raloxifene and alendronate containing thin mesoporous titanium oxide films improve implant fixation to bone.

Necati Harmankaya ; Johan Karlsson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Anders Palmquist ; Mats Halvarsson (Institutionen för teknisk fysik, Materialens mikrostruktur ) ; K Igawa ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Pentti Tengvall
Acta biomaterialia (1742-7061). Vol. 9 (2013), 6, p. 7064-73.
[Artikel, refereegranskad vetenskaplig]

This study tested the hypothesis that osteoporosis drug-loaded mesoporous TiO2 implant coatings can be used to improve bone-implant integration. Two osteoporosis drugs, Alendronate (ALN) and Raloxifene (RLX), were immobilized in nanoporous oxide films prepared on Ti screws and evaluated in vivo in rat tibia. The drug release kinetics were monitored in vitro by quartz crystal microbalance with dissipation and showed sustained release of both drugs. The osteogenic response after 28days of implantation was evaluated by quantitative polymerase chain reaction (qPCR), removal torque, histomorphometry and ultrastructural interface analysis. The drug-loaded implants showed significantly improved bone fixation. In the case of RLX, stronger bone-remodelling activity was observed compared with controls and ALN-loaded implants. The ultrastructural interface analysis revealed enhanced apatite formation inside the RLX coating and increased bone density outside the ALN coating. Thus, this novel combination of a thin mesoporous TiO2 carrier matrix and appropriate drugs can be used to accelerate implant fixation in trabecular bone.

Nyckelord: Mesoporous, Titanium, Drug delivery, Bisphosphonate, Raloxifene

Denna post skapades 2013-05-29. Senast ändrad 2014-02-11.
CPL Pubid: 177618


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Institutioner (Chalmers)

Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för biomaterialvetenskap (GU)
Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)
Institutionen för teknisk fysik, Materialens mikrostruktur (2012-2015)



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