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The Model Muddle: In Search of Tumor Growth Laws

Philip Gerlee (Institutionen för matematiska vetenskaper, matematik ; Sahlgrenska Cancer Center)
Cancer Research (0008-5472). Vol. 73 (2013), 8, p. 2407-2411.
[Artikel, refereegranskad vetenskaplig]

In this article, we will trace the historical development of tumor growth laws, which in a quantitative fashion describe the increase in tumor mass/volume over time. These models are usually formulated in terms of differential equations that relate the growth rate of the tumor to its current state and range from the simple one-parameter exponential growth model to more advanced models that contain a large number of parameters. Understanding the assumptions and consequences of such models is important, as they often underpin more complex models of tumor growth. The conclusion of this brief survey is that although much improvement has occurred over the last century, more effort and new models are required if we are to understand the intricacies of tumor growth.

Nyckelord: tritiated thymidine, breast-cancer, dynamics, curves, mice

Denna post skapades 2013-05-27. Senast ändrad 2016-06-30.
CPL Pubid: 177448


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Institutioner (Chalmers)

Institutionen för matematiska vetenskaper, matematik (2005-2016)
Sahlgrenska Cancer Center (GU)


Cancer och onkologi

Chalmers infrastruktur