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Where bone meets implant: the characterization of nano-osseointegration

Kathryn Grandfield ; Stefan Gustafsson (Institutionen för teknisk fysik, Eva Olsson Group ; SuMo Biomaterials) ; Anders Palmquist
Nanoscale (2040-3364). Vol. 5 (2013), 10, p. 4302-8.
[Artikel, refereegranskad vetenskaplig]

The recent application of electron tomography to the study of biomaterial interfaces with bone has brought about an awareness of nano-osseointegration and, to a further extent, demanded increasingly advanced characterization methodologies. In this study, nanoscale osseointegration has been studied via laser-modified titanium implants. The micro- and nano-structured implants were placed in the proximal tibia of New Zealand white rabbits for six months. High-resolution transmission electron microscopy (HRTEM), analytical microscopy, including energy dispersive X-ray spectroscopy (EDXS) and energy-filtered TEM (EFTEM), as well as electron tomography studies were used to investigate the degree of nano-osseointegration in two- and three-dimensions. HRTEM indicated the laser-modified surface encouraged the formation of crystalline hydroxyapatite in the immediate vicinity of the implant. Analytical studies suggested the presence of a functionally graded interface at the implant surface, characterized by the gradual intermixing of bone with oxide layer. Yet, the most compelling of techniques, which enabled straightforward visualization of nano-osseointegration, proved to be segmentation of electron tomographic reconstructions, where thresholding techniques identified bone penetrating into the nanoscale roughened surface features of laser-modified titanium. Combining high-resolution, analytical and three-dimensional electron microscopy techniques has proven to encourage identification and understanding of nano-osseointegration.

Nyckelord: Osseointegration, ultrastructure, electron tomography



Denna post skapades 2013-05-22. Senast ändrad 2016-03-21.
CPL Pubid: 177203

 

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Institutioner (Chalmers)

Institutionen för teknisk fysik, Eva Olsson Group (2012-2015)
SuMo Biomaterials
Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för biomaterialvetenskap (GU)

Ämnesområden

Biomaterialvetenskap

Chalmers infrastruktur