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Regulatory Effects of Cu, Zn, and Ca on Fe Absorption: The Intricate Play between Nutrient Transporters

Nathalie Scheers (Institutionen för kemi- och bioteknik, Livsmedelsvetenskap)
Nutrients (2072-6643). Vol. 5 (2013), 3, p. 957-970.
[Artikel, refereegranskad vetenskaplig]

Iron is an essential nutrient for almost every living organism because it is required in a number of biological processes that serve to maintain life. In humans, recycling of senescent erythrocytes provides most of the daily requirement of iron. In addition, we need to absorb another 1-2 mg Fe from the diet each day to compensate for losses due to epithelial sloughing, perspiration, and bleeding. Iron absorption in the intestine is mainly regulated on the enterocyte level by effectors in the diet and systemic regulators accessing the enterocyte through the basal lamina. Recently, a complex meshwork of interactions between several trace metals and regulatory proteins was revealed. This review focuses on advances in our understanding of Cu, Zn, and Ca in the regulation of iron absorption. Ascorbate as an important player is also considered.

Nyckelord: iron, absorption, Fe, Zn, Cu, Ca, ascorbate, intestinal epithelial-cells, duodenal cytochrome-b, iron-absorption, dietary iron, caco-2 cells, hepcidin expression, ascorbic-acid, fpn1, transcription, copper transporter, nramp2 expression

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Denna post skapades 2013-04-29. Senast ändrad 2013-04-29.
CPL Pubid: 176327


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Livsmedelsvetenskap (2005-2014)


Biologiska vetenskaper

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