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Toward Quantifying the Thymic Dysfunctional State in Mouse Models of Inflammatory Bowel Disease

A. Jansson ; A. K. Pernestig ; P. Nilsson ; Mats Jirstrand (Institutionen för kemi- och bioteknik, Systembiologi) ; E. H. Hornquist
Inflammatory Bowel Diseases (1078-0998). Vol. 19 (2013), 4, p. 881-888.
[Artikel, refereegranskad vetenskaplig]

Inflammatory bowel disease is characterized by a number of immunological alterations, not the least in the T-cell compartment. Numerous animal models of colitis have revealed aberrant thymocyte dynamics associated with skewed thymocyte development. The recent advancements in quantitative methods have proposed critical kinetic alterations in the thymocyte development during the progression of colitis. This review focuses on the aberrant thymocyte dynamics in G alpha i2-deficient mice as this mouse model provides most quantitative data of the thymocyte development associated with colitis. Herein, we discuss several dynamic changes during the progression of colitis and propose a hypothesis for the underlying causes for the skewed proportions of the thymocyte populations seen in the G alpha i2-deficient mice and in other mouse models of colitis.

Nyckelord: kinetics, thymocyte, thymus, IBD, colitis

Denna post skapades 2013-04-22. Senast ändrad 2014-12-09.
CPL Pubid: 175880


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Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)



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