CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth

J. G. Scott ; D. Basanta ; A. R. A. Anderson ; Philip Gerlee (Institutionen för matematiska vetenskaper, matematik)
Journal of the Royal Society Interface (1742-5662). Vol. 10 (2013), 82, p. Art. no. 20130011.
[Artikel, refereegranskad vetenskaplig]

Two models of circulating tumour cell (CTC) dynamics have been proposed to explain the phenomenon of tumour 'self-seeding', whereby CTCs repopulate the primary tumour and accelerate growth: primary seeding, where cells from a primary tumour shed into the vasculature and return back to the primary themselves; and secondary seeding, where cells from the primary first metastasize into a secondary tissue and form microscopic secondary deposits, which then shed cells into the vasculature returning to the primary. These two models are difficult to distinguish experimentally, yet the differences between them is of great importance to both our understanding of the metastatic process and also for designing methods of intervention. Therefore, we developed a mathematical model to test the relative likelihood of these two phenomena in the subset of tumours whose shed CTCs first encounter the lung capillary bed, and show that secondary seeding is several orders of magnitude more likely than primary seeding. We suggest how this difference could affect tumour evolution, progression and therapy, and propose several possible methods of experimental validation.

Nyckelord: metastasis, circulating tumour cells, mathematical model, cancer, breast-cancer metastasis, cells, evolution, blood, disease, heterogeneity, morphology, survival, vessels, genes



Denna post skapades 2013-04-19. Senast ändrad 2016-06-30.
CPL Pubid: 175843

 

Läs direkt!


Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för matematiska vetenskaper, matematik (2005-2016)

Ämnesområden

Matematik

Chalmers infrastruktur