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Chemical Analysis of Single Cells

Raphaël Trouillon ; M. K. Passarelli ; J. Wang ; Michael E. Kurczy (Institutionen för kemi- och bioteknik, Analytisk kemi) ; Andrew G Ewing (Institutionen för kemi- och bioteknik, Analytisk kemi)
Analytical Chemistry (0003-2700). Vol. 85 (2013), 2, p. 522-542.
[Artikel, forskningsöversikt]

In this Review, we provide an overview of methods developed for chemical analysis of single cells over the last two years. Many biological systems contain an ensemble of cells with heterogeneous chemistry; therefore, it is important to analyze them on an individual basis in order to elucidate the role each cell plays in the function of these systems. In clinical diagnostics, the development of extremely sensitive measurements, down to single cells, may provide the best ability for diagnoses. Single cell analysis has, in fact, been present for quite some time. Investigators in life sciences consider the cell as the unit of life and so the pursuit to quantify, image, and modulate the cell has been ongoing for decades.

Nyckelord: scanning electrochemical microscopy, ion mass-spectrometry, in-vivo, droplet microfluidics, living cells, multifunctional pipette, neuroendocrine cells, fluorescent protein, sample preparation, reactive, oxygen



Denna post skapades 2013-03-04. Senast ändrad 2013-03-06.
CPL Pubid: 174343

 

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Institutioner (Chalmers)

Institutionen för kemi och molekylärbiologi (GU)
Institutionen för kemi- och bioteknik, Analytisk kemi (2006-2014)

Ämnesområden

Analytisk kemi

Chalmers infrastruktur