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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

Margareta Jernås ; Intawat Nookaew (Institutionen för kemi- och bioteknik, Systembiologi) ; Hans Wadenvik ; Bob Olsson
Blood (1528-0020). Vol. 121 (2013), 11, p. 2095-2098.
[Artikel, refereegranskad vetenskaplig]

MicroRNA are small non-coding RNA molecules that regulate gene expression. To investigate the role of microRNA in ITP, we performed genome-wide expression analyses of mRNA and microRNA in T-cells from ITP patients and controls. We identified 1,915 regulated genes and 22 regulated microRNA that differed between ITP patients and controls. Seventeen of the 22 regulated microRNA were linked to changes in target gene expression; 57 of these target genes were associated with the immune system, e.g. T-cell activation and regulation of immunoglobulin production. CXCL13 and IL-21 were two microRNA target genes significantly increased in ITP. We could demonstrate increased plasma levels of CXCL13 and others have reported increased plasma levels of IL-21 in ITP. Thus, regulated microRNA were significantly associated with both gene and protein expression of molecules in immunological pathways. We suggest that microRNA may be important regulatory molecules involved in the loss of tolerance in ITP.

Nyckelord: Case-Control Studies, Cluster Analysis, Gene Expression Profiling, Humans, Microarray Analysis, MicroRNAs



Denna post skapades 2013-01-21. Senast ändrad 2013-09-12.
CPL Pubid: 171920

 

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Institutioner (Chalmers)

Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (GU)
Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (GU)

Ämnesområden

Hematologi

Chalmers infrastruktur