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Nano Hydroxyapatite-coated Implants Improve Bone Nanomechanical Properties

R. Jimbo ; P. G. Coelho ; M. Bryington ; M. Baldassarri ; N. Tovar ; F. Currie ; M. Hayashi ; M. N. Janal ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; D. Ono ; S. Vandeweghe ; A. Wennerberg
Journal of Dental Research (0022-0345). Vol. 91 (2012), 12, p. 1172-1177.
[Artikel, refereegranskad vetenskaplig]

Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acid-etched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.

Nyckelord: osseointegration, dental implants, calcium phosphate, nanostructures, biomechanics, histology, mechanical-properties, mineral-content, titanium, surfaces, tissue, topography, modulus, dogs

Denna post skapades 2013-01-16.
CPL Pubid: 170938


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)



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